Searchable abstracts of presentations at key conferences in endocrinology

ea0010dp3 | Diabetes, metabolism and cardiovascular | SFE2005

Modulation of nicotine and advanced glycation end product (AGE) mediated effects by the antioxidant glutathione (G) in fibroblasts

Soory a M , Rahman Z

Aims Nicotine (N) has detrimental effects on fibroblasts compounding those of AGE in uncontrolled diabetes. The impact of the antioxidant glutathione (G) is investigated to clarify mechanisms involved, using 5 alpha dihydrotestosterone (DHT) as a hormone marker of healing.MethodsHuman gingival fibroblasts in confluent culture were incubated in Eagle’s MEM, with 14C-testosterone / 14C-4-androstenedione an...